In male rats that lack androgen receptors, which of the following outcomes are likely to occur? Select all that apply.Group of answer choicesIncreased sensitivity to testosterone in the medial preoptic area (MPOA) and other brain regions.Reduced dopamine release in the MPOA during sexual arousal.Impaired development of male-specific brain structures and neural circuits.Decreased testosterone production by the testes.Feminization of external genitalia and secondary sexual characteristics
Question
In male rats that lack androgen receptors, which of the following outcomes are likely to occur? Select all that apply.Group of answer choicesIncreased sensitivity to testosterone in the medial preoptic area (MPOA) and other brain regions.Reduced dopamine release in the MPOA during sexual arousal.Impaired development of male-specific brain structures and neural circuits.Decreased testosterone production by the testes.Feminization of external genitalia and secondary sexual characteristics
Solution
The outcomes likely to occur in male rats that lack androgen receptors include:
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Impaired development of male-specific brain structures and neural circuits: Androgen receptors are crucial for the development and maintenance of male-specific brain structures. Without these receptors, testosterone and other androgens cannot exert their effects, leading to impaired development.
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Reduced dopamine release in the MPOA during sexual arousal: Dopamine release in the MPOA is stimulated by androgens. Without androgen receptors, this stimulation cannot occur, leading to reduced dopamine release.
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Feminization of external genitalia and secondary sexual characteristics: Androgens are responsible for the masculinization of external genitalia and secondary sexual characteristics. Without androgen receptors, these hormones cannot exert their effects, leading to feminization.
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Decreased testosterone production by the testes: Androgen receptors are involved in the regulation of testosterone production. Without these receptors, testosterone production may be decreased.
Increased sensitivity to testosterone in the medial preoptic area (MPOA) and other brain regions is not a likely outcome. Without androgen receptors, testosterone cannot exert its effects, regardless of the level of sensitivity.
Similar Questions
A male patient undergoing treatment with a dopamine antagonist reports experiencing reduced sexual arousal. Which of the following best explains the underlying mechanism?Group of answer choicesThe dopamine antagonist increases the release of inhibitory GABA neurotransmitters in the medial preoptic area (MPOA), leading to decreased sexual arousal.The dopamine antagonist directly lowers testosterone levels, reducing touch sensitivity in the penis and causing decreased sexual arousal.The dopamine antagonist blocks the action of dopamine released by MPOA neurons, which are primed by testosterone during sexual arousal, resulting in reduced arousal.The dopamine antagonist enhances the effect of testosterone on the MPOA, leading to excessive dopamine release and causing decreased sexual arousal through overstimulation.
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