Martin, a 25-year-old male, has recently been diagnosed with a mitochondrial disease and is seeking information. You know that mitochondrial disease is a genetic disease caused by a mutation in one of the 22 autosomal chromosomes leading to a reduced function of the mitochondria. Question 11. Martin asks if his exhaustion is associated with his disease – knowing the function of the mitochondria, what would you say to Martin (in lay terms)? (2 marks) Question 12. Martin is concerned about his future children inheriting the disease. Answer the following questions regarding inheritance patterns (you might like to use punnet squares to help you prepare your response, but they don’t need to be included in your answer). (6 marks) a) If both parents are carriers (heterozygous) for a recessively inherited gene, what percentage of offspring will manifest the disease? b) If only one parent contains a single copy (heterozygous) of a dominantly inherited disorder and the other parent is homozygous recessive, what percentage of offspring will have the disorder? c) A mother is a carrier for an X-linked disease, what percentage of males will manifest the disease? And what percentage of females will manifest the disease? d) Explain why there is a difference in X-linked inheritance patterns.

Martin is concerned about his future children inheriting the disease. Answer the following questions regarding inheritance patterns (you might like to use punnet squares to help you prepare your response, but they don’t need to be included in your answer). A mother is a carrier for an X-linked disease, what percentage of males will manifest the disease? And what percentage of females will manifest the disease? answer: The male offspring of the mother will have 50% of manifesting the disease, and there will be none for the female offspring. However, the female offspring will be the carriers of the disease with 50%. is the statement correct?

A pedigree diagram of a disorder caused by a mitochondrial DNA mutation will show:Group of answer choicesmales and females affected equally, affected children have at least one affected parent, and that heterozygotes are affected.more males than females are affected, affected sons can have parents with normal phenotypes, affected female offspring have an affected father, and the mother must be affected or be a carrier.all of the offspring of an affected female are affected.males and females affected equally, affected children can have unaffected parents, and that heterozygotes have a normal phenotype.males and females affected equally, heterozygotes have a normal phenotype, and affected children can have unaffected parents.

A pedigree diagram shows males and females affected equally, heterozygotes have a normal phenotype, and affected children can have unaffected parents.Group of answer choicesautosomal recessive disordersex-linked disorderautosomal dominant disordermitochondrial disorder

A pedigree diagram showing an inheritance pattern in which all of the offspring of an affected female are affected.Group of answer choicessex-linked recessiveautosomal dominantautosomal recessivemitochondrial DNA mutationsex-linked dominantNext

To inherit an autosomal dominant disorder a person could receive the allele leading to the disease fromMultiple Choicethe father only, not the mother.the mother only, not the father.the mother or the father.the parent who does not exhibit the disease.All answers are correct.