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Discuss the characteristics and life cycle of retrovirus.

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Discuss the characteristics and life cycle of retrovirus.

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Solution

Retroviruses are a family of viruses that are defined by their replication process, which is unique among RNA viruses. They are enveloped viruses that contain two copies of a single-stranded RNA genome. The key characteristics of retroviruses include:

  1. Reverse Transcription: Retroviruses are unique in that they replicate their RNA genomes by reverse transcription, a process carried out by the viral enzyme reverse transcriptase. This enzyme synthesizes a DNA copy of the virus's RNA genome, which is then integrated into the host cell's genome.

  2. Integration: The DNA copy of the viral genome is integrated into the host cell's genome by the viral enzyme integrase. This allows the virus to effectively hide within the host cell and evade the immune system.

  3. Enveloped Viruses: Retroviruses are enveloped viruses, meaning they have a lipid bilayer membrane derived from the host cell. Embedded in this envelope are viral proteins that allow the virus to bind to and enter host cells.

  4. Oncogenic Potential: Some retroviruses are oncogenic, meaning they have the potential to cause cancer. They do this by integrating their genomes into host cell DNA in a way that disrupts the normal regulation of cell growth and division.

The life cycle of a retrovirus involves several steps:

  1. Attachment and Entry: The virus attaches to a host cell and fuses its envelope with the cell membrane, releasing the viral RNA genome and enzymes into the cell.

  2. Reverse Transcription: The viral enzyme reverse transcriptase synthesizes a DNA copy of the viral RNA genome.

  3. Integration: The viral enzyme integrase integrates the DNA copy of the viral genome into the host cell's DNA.

  4. Transcription and Translation: The host cell's machinery transcribes and translates the integrated viral DNA, producing viral proteins.

  5. Assembly and Release: New virus particles are assembled and then released from the cell, ready to infect more cells.

This cycle can result in the destruction of the infected cell and the spread of the virus to other cells. However, some retroviruses can also enter a latent phase, where the integrated viral DNA remains dormant within the host cell's genome. This allows the virus to persist in the host for long periods of time.

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Which of the following models best depicts how the genetic information in a retrovirus is eventually translated into proteins?Choose 1 answer:Choose 1 answer:(Choice A)   DNA in the retrovirus → mRNA in the host cell → ProteinsADNA in the retrovirus → mRNA in the host cell → Proteins(Choice B)   RNA in the retrovirus → DNA in the host cell → RNA in the host cell → ProteinsBRNA in the retrovirus → DNA in the host cell → RNA in the host cell → Proteins(Choice C)   DNA in the retrovirus → RNA in the host cell → ProteinsCDNA in the retrovirus → RNA in the host cell → Proteins(Choice D)   RNA in the retrovirus → mRNA in the host cell → ProteinsDRNA in the retrovirus → mRNA in the host cell → Proteins

In the 1970s, researchers studying the human genome discovered that humans have viruses in their DNA. These so-called human endogenous retroviruses (HERVs) represent remnants of once-infectious viruses that became fixed in our genome. While some of them still have the potential to produce virus-like particles, HERVs have lost their ability to generate infectious virions. _______ they persist in our DNA as viral fossils that are passed on from generation to generation.Which choice completes the text with the most logical transition?

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