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The sequence below is a portion of exon 7 of the SMN1 mRNA transcript:5′ – UCAAGUGAUUCUCCU – 3′Which of the following represents the corresponding DNA coding strand sequence for this transcript?A.5′ – AGGAGAATCACTTGA – 3′B.5′ – TCCTCTTAGTGAACT – 3′C.5′ – AGTTCACTAAGAGGA – 3′D.5′ – TCAAGTGATTCTCCT – 3′

Question

The sequence below is a portion of exon 7 of the SMN1 mRNA transcript:5′ – UCAAGUGAUUCUCCU – 3′Which of the following represents the corresponding DNA coding strand sequence for this transcript?A.5′ – AGGAGAATCACTTGA – 3′B.5′ – TCCTCTTAGTGAACT – 3′C.5′ – AGTTCACTAAGAGGA – 3′D.5′ – TCAAGTGATTCTCCT – 3′

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Solution

The correct answer is D.5′ – TCAAGTGATTCTCCT – 3′

Here's the step-by-step explanation:

  1. The mRNA sequence is 5′ – UCAAGUGAUUCUCCU – 3′.

  2. mRNA is transcribed from the template strand of DNA, and it is complementary to it. In DNA, A pairs with T, and C pairs with G. In RNA, A pairs with U, and C pairs with G.

  3. However, the question asks for the DNA coding strand, not the template strand. The coding strand of DNA has the same sequence as the mRNA, except T is substituted for U.

  4. Therefore, the DNA coding strand corresponding to the given mRNA sequence is 5′ – TCAAGTGATTCTCCT – 3′, which is option D.

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