Which of the following statements best describes an important characteristic of the general steroid hormone receptor mechanism of action?Group of answer choicesSteroid receptors are bound to response elements even before binding to their ligand.Coactivator complexes that are recruited to ligand bound receptor remove acetyl groups from histones.Steroid hormone receptors are bound to heat shock proteins (hsps) in the inactive state before binding to a hormone.Helix 12 of the ligand binding domain is always positioned the same way regardless of binding to an agonist or an antagonist.Steroid receptors are always found in the nuclear cell membrane, which is why they are called nuclear receptors.
Question
Which of the following statements best describes an important characteristic of the general steroid hormone receptor mechanism of action?Group of answer choicesSteroid receptors are bound to response elements even before binding to their ligand.Coactivator complexes that are recruited to ligand bound receptor remove acetyl groups from histones.Steroid hormone receptors are bound to heat shock proteins (hsps) in the inactive state before binding to a hormone.Helix 12 of the ligand binding domain is always positioned the same way regardless of binding to an agonist or an antagonist.Steroid receptors are always found in the nuclear cell membrane, which is why they are called nuclear receptors.
Solution
The statement that best describes an important characteristic of the general steroid hormone receptor mechanism of action is: "Steroid hormone receptors are bound to heat shock proteins (hsps) in the inactive state before binding to a hormone."
This is because steroid hormones are lipophilic and can pass through the cell membrane to interact with intracellular receptors. In the absence of the hormone, these receptors are often bound to heat shock proteins (hsps) which keep them in an inactive state. Upon binding to the hormone, the receptor undergoes a conformational change, releases the hsp, and becomes active. The activated receptor can then bind to specific DNA sequences and regulate gene expression.
Similar Questions
When a steroid hormone binds to its target cell receptor, it:Group of answer choicesalters the membrane’s permeability to G proteins.is converted into cholesterol, which acts as a second messenger.causes the formation of releasing hormones.turns specific genes of the nuclear DNA on or off.causes the formation of cyclic AMP
Steroid hormones result in:Group of answer choicesdirect gene activationhormone binding to a membrane-bound receptoractivation of a G proteinactivation of adenylate cyclaseproduction of 2nd messengersall of theseNext
Which of the following is true about steroid hormones?Multiple ChoiceSteroid hormones can diffuse through the lipid bilayer.Receptors for steroid hormones are found on the cell membrane.Steroid hormones use a second messenger mechanism to cause an effect in the cell.Steroid hormones can travel freely in the blood.
What do steroid and peptide hormones typically have incommon?(A) their solubility in cell membranes(B) their requirement for travel through the bloodstream(C) the location of their receptors(D) their reliance on signal transduction in the cell
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