Scientistdevelop lines of hybridoma cells to assure a consistent supply of a definedantibody. They do this by fusing a B(plasma) cell with a myleoma (B cancer) cell. What necessary function or ability does the myeloma cell supply to thehybrid cell? 1 point specificationof the CDR (recognition region) of the antibody instructionsfor the Fc stem region of the antibody capacityto avoid apoptosis and continue dividing enzymesto synthesize nucleotides de novoA and BB and C

For hybridoma technology (image on the left), rodents are immunized with the antigen and when a sufficient immune response is detected, antibody-producing cells are fused with a myeloma cell line and screened.

What is injected into mice during the first step of monoclonal antibody production?Spleen cellsAntibodiesLymphocytesAntigens2What are myeloma cells?Spleen cellsCancerous red blood cellsCancerous white blood cellsMouse lymphocytes3What cells are fused together to make hybridoma cells? Myeloma cells with red blood cellsLymphocytes with spleen cellsMyeloma cells with nerve cellsLymphocytes with myeloma cells4Which of the following best describes the properties of a hybridoma cell? They can make monoclonal antibodies but cannot divideThey can divide but cannot make monoclonal antibodiesThey cannot make monoclonal antibodies or divideThey can make monoclonal antibodies and can divide5How can monoclonal antibodies be used to treat cancer? By triggering the immune system to attack cancer cellsBy binding to receptors on cancer cells, preventing them from growing and dividingAll three of the ways listed hereBy carrying drugs or radioactive therapies directly to cancer cells6Which of the following is an example of an ethical issue concerning monoclonal antibodies? They require the use of mouse cellsThey can be used to test for various diseasesThey can produce unwanted side effectsThey are very expensive to make

Antibodies can be produced by two types of cells: hybridoma cells and what other type?

Which of the following is a common feature between T and B cells?ANSWERBoth will undergo proliferation and differentiation to make plasma cells.Both mature in the bone marrow.Both require an antigen-presenting cell to become activated.Both produce memory cells after activation.

The name given to a fully activated and differentiated B cell that secretes antibody isGroup of answer choicesT cellantigen-presenting cellhematopoietic cellsecretory cellplasma cell