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Misfolded proteins cause which of the following adaptive response in cells?Select one:a. Protease activationb. Increased chaperone proteinsc. Lipid peroxidationd. Caspase activationClear my choice

Question

Misfolded proteins cause which of the following adaptive response in cells?Select one:a. Protease activationb. Increased chaperone proteinsc. Lipid peroxidationd. Caspase activationClear my choice

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Solution

The correct answer is b. Increased chaperone proteins.

Here's why:

Misfolded proteins in cells trigger a response known as the unfolded protein response (UPR). The UPR is an adaptive response that attempts to restore normal function by stopping protein translation and activating signals to increase the production of molecular chaperones.

Molecular chaperones are proteins that assist in the folding of other proteins. When there is an accumulation of misfolded proteins, the cell increases the production of these chaperones to help refold these proteins back into their correct shape or, if refolding is not possible, to direct them towards degradation pathways.

Therefore, the presence of misfolded proteins in a cell would not directly cause protease activation (option a), lipid peroxidation (option c), or caspase activation (option d). These processes may occur in a cell under stress or undergoing apoptosis,

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