Which one of the following statements about peptide biosynthesis is TRUE?Question 6Select one:a.The signal sequence is cleaved in the golgi apparatus to produce an active hormone.b.The signal sequence transcribed from the mRNA strand directs the early inactive protein to attach to the golgi apparatus.c.C-peptide is the active form of insulin contained within vesicles in the pancreatic beta cell.d.During the biosynthesis of insulin, the golgi apparatus receives proinsulin from the endoplasmic reticulum.e.Preprohormone is stored in vesicles and awaits the right conditions to undergo exocytosis from the cell.

The process of converting proinsulin into mature insulin involves: (1 Point)a) Cleaving off the C-peptide segmentb) Adding a signal peptidec) Attaching disulfide bondsd) All of the above

Which one of the following statements is INCORRECT? Question 16Select one:a.Insulin stimulates the production of glycogen synthase enzyme, which favours glycogenesis in hepatocytes.b.Peptidase enzymes in the enterocyte cytoplasm degrade absorbed peptides into amino acids.c.Lipid storage ceases during fasting because there are minimal levels of insulin in the blood to synthesise lipoprotein lipase enzymed.The insulin receptor is a tyrosine kinase receptor that is comprised of 4 subunits: 2 membrane-spanning alpha subunits, and 2 insulin-binding beta subunits.e.Glucose enters the liver via the GLUT2 transporter, which is active regardless of the presence of insulin.

Which one of the following statements about the biochemical pathway for glucose-stimulated insulin secretion from the pancreas is INCORRECT?Question 4Select one:a.Glucose enters the pancreatic beta cell via GLUT2 transporters.b.The endoplasmic reticulum assists exocytosis of insulin from the beta cell.c.Glucose enters the pancreatic beta cell where it is used to fuel glycolysis and the Krebs cycle.d.Opened voltage-gated calcium channels are the only source of Ca2+ that triggers the release of insulin via exocytosis.e.ATP inhibits potassium (K+) channels on the cell membrane.

Which of the following statements best describes leptin?Group of answer choicesA short-term acting peptide hormone synthesised in the stomach that binds to receptors in the hypothalamus to initiate feeding behaviour.A protein that has its levels regulated by feeding status, which results in obesity when overexpressed.A peptide hormone product of the POMC gene that binds to receptors in the paraventricular nucleus to inhibit feeding behaviour.A long-term acting hormone released from adipose tissue that binds to receptors in the hypothalamus to inhibit feeding behaviour.

After the bacterial cells are transformed with the human insulin gene, they produce: (1 Point)Critical Thinking Questiona) Proinsulinb) Mature insulinc) Both proinsulin and mature insulind) Neither proinsulin nor mature insulin