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Which of the following best defines a compound that binds non-covalently to the active site of an enzyme to block its activity? A product An irreversible inhibitor An affinity label A substrate A competitive inhibitor

Question

Which of the following best defines a compound that binds non-covalently to the active site of an enzyme to block its activity? A product An irreversible inhibitor An affinity label A substrate A competitive inhibitor

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Solution

A compound that binds non-covalently to the active site of an enzyme to block its activity is best defined as a competitive inhibitor.

Here's why:

  1. A product is what is formed after the enzyme has catalyzed a reaction, so it doesn't block the enzyme's activity.

  2. An irreversible inhibitor binds to the enzyme and permanently deactivates it, usually through a covalent bond, not a non-covalent one.

  3. An affinity label is a molecule that binds to an enzyme and then covalently modifies it, which is not the case here.

  4. A substrate is a molecule upon which an enzyme acts to carry out a chemical reaction, not to block its activity.

  5. A competitive inhibitor competes with the substrate for the

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