During the process of keratinization, the cell's and organelles disintegrate and the cells start to die.

During the process of keratinization, the cells undergo a series of changes. Here are the steps:

1. Basal Cells: The process begins in the basal layer of the skin, where the keratinocytes are produced. These are the cells that will eventually become keratinized.

2. Cell Division: The keratinocytes begin to divide and move up through the layers of the skin. As they move up, they start to produce keratin, a protein that gives skin, hair, and nails their hard, protective properties.

3. Keratin Production: As the cells continue to move up, they produce more and more keratin. This process is regulated by various factors, including the body's need for protection and the availability of essential nutrients.

4. Cell Death: Eventually, the cells reach the outermost layer of the skin, the stratum corneum. By this point, the cells' nuclei and organelles have disintegrated, and the cells themselves are dead. However, they are still serving a purpose, as they are now filled with keratin.

5. Desquamation: The final step in the process is desquamation, or shedding. The dead, keratin-filled cells are sloughed off the surface of the skin to make way for new cells coming up from below.

So, in summary, during the process of keratinization, the cells' nuclei and organelles disintegrate, and the cells start to die. However, they continue to serve a protective function by producing keratin and forming the outermost layer of the skin.