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Which of the following correctly matches an enzyme with its cofactor?Group of answer choicesalanine aminotransferase -- pyridoxal phosphate (PLP)nitrate reductase -- tetrahydrofolate (THF)branched chain alpha keto acid dehydrogenase complex -- thiamine pyrophosphate (TPP)glutamate dehydrogenase – NAD(P)H/ NAD(P)+two or more of the above are correct

Question

Which of the following correctly matches an enzyme with its cofactor?Group of answer choicesalanine aminotransferase -- pyridoxal phosphate (PLP)nitrate reductase -- tetrahydrofolate (THF)branched chain alpha keto acid dehydrogenase complex -- thiamine pyrophosphate (TPP)glutamate dehydrogenase – NAD(P)H/ NAD(P)+two or more of the above are correct

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Solution

The correct match of an enzyme with its cofactor from the given options is:

  1. Alanine aminotransferase -- Pyridoxal phosphate (PLP)
  2. Branched chain alpha keto acid dehydrogenase complex -- Thiamine pyrophosphate (TPP)

So, the answer is "two or more of the above are correct".

Explanation:

Alanine aminotransferase (ALT) is an enzyme that catalyzes the transfer of an amino group from alanine to α-ketoglutarate. The products of this reaction are glutamate and pyruvate. Pyridoxal phosphate (PLP) is the active form of vitamin B6 and acts as a cofactor in this reaction.

Branched chain alpha keto acid dehydrogenase complex is a multi-enzyme complex that catalyzes the oxidative decarboxylation of branched-chain alpha-keto acids. Thiamine pyrophosphate (TPP) is a cofactor that is essential for the enzyme's activity.

Nitrate reductase does not use tetrahydrofolate (THF) as a cofactor. Instead, it uses molybdenum.

Glutamate dehydrogenase uses NAD(P)+ as a cofactor, but not NAD(P)H. The enzyme catalyzes the reversible oxidative deamination of glutamate to α-ketoglutarate and ammonia while reducing NAD+ and/or NADP+ to NADH and/or NADPH.

This problem has been solved

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