A 50 year-old woman was found to have a blood pressure of 158/90 during a routine visit. Her Past medical was significant for a second-degree heart block and for osteoporosis. One year ago she had suffered from a severe episode of angioedema. Recommend an appropriate antihypertensive drug for this patient?Question 9Answera.Enalaprilb.Hydrochlorothiazidec.Ramiprild.Diltiazeme.Furosemide

A man recently diagnosed with stage 1 hypertension, started a treatment with hydrochlorothiazide. After several weeks of treatment, the antihypertensive action of the drug was most likely associated with which of the following effects?Question 2Answera.Decreased renal blood flowb.Increased interstitial fluid volumec.Decreased peripheral vascular resistanced.Decreased cardiac outpute.Remarkable postural hypotension

A 44-year-old woman maintained on Irbesartan and Terbutaline was noted to have blood pressure elevations for the past two weeks. What drug would you avoid in this patient?*1 pointAtenololBisoprololCeliprololPropanololNebivolol

High blood pressure, or hypertension, is a prevalent condition in the United States.  One in three adults has hypertension, and approximately 20% do not know that they have it.  If left untreated, high blood pressure can lead to major health issues, including stroke, heart attack, and kidney disease or failure.  Several drugs can help control hypertension, including those shown in Table 1.  These drugs can be classified into different groups based on their mechanism of action.Table 1  Drugs Used to Treat High Blood PressureDrug Mechanism of actionLabetalol Combined α- and β-blockerReserpine Peripheral adrenergic inhibitorValsartan Angiotensin II receptor blockerEprosartan mesylate Angiotensin II receptor blockerVerapamil hydrochloride Calcium channel blockerMinoxidil VasodilatorsCaptopril Angiontensin converting enzyme inhibitorsLabetalol (Figure 1) exists as four stereoisomers and is administered as a mixture of all four.  This drug can be classified as a pseudohybrid drug because two of the isomers, (R,R) and (S,R), exhibit biological activity; the other two isomers, (S,S) and (R,S), are not active.  The (R,R) isomer acts as a nonselective β-adrenergic receptor blocker, and the (S,R) isomer acts as a selective α-adrenergic receptor blocker.Figure 1  Structure of (±)-labetalol and l-epinephrinel-Epinephrine (Figure 1) is the agonist of the α- and β-adrenergic receptors.  The structural motifs that allow l-epinephrine to bind to the adrenergic receptors include an amine separated from an aromatic ring by two carbon units, a hydroxyl group at a chiral center beta to the amine, and two hydroxyl groups on the aromatic ring in the meta and para positions.  With a few structural modifications, the agonist l-epinephrine can be converted into the antagonist labetalol.  Substitution of a hydroxyl on the aromatic ring with an amide group and extension of the methyl group on the amine transforms l-epinephrine into labetalol.  These substitutions keep most of the structural motifs necessary for labetalol to mimic l-epinephrine and bind to the adrenergic receptors. Question 7The number of stereoisomers possible for a given molecule is 2n.  The variable n denotes the number of:A.enantiomers.B.stereocenters.C.diastereomers.D.epimers.

A 52-year-old male is diagnosed with primary hypertension. He could be treated with a drug that acts by which of the following mechanisms?Group of answer choicesangiotensin ll agonistcalcium channel agonistbeta-adrenergic agonistdiuretic

A 52-year-old man complained to his physician of acute pain at the base of his right big toe. The man, who had been working as a painter for 15 years, was recently diagnosed with essential hypertension and started an antihypertensive therapy one month ago. A lab test showed a plasma uric acid level of 17 mg/dL. Which of the following drugs might have caused the symptoms and signs of this patient?Question 8Answera.Methyldopab.Furosemidec.Minoxidild.Prazosine.Hydrochlorothiazide