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Which of the following is NOT involved in the induction of long-term depression in Purkinje cells in the cerebellum?Group of answer choicesActivation of NMDA receptorsActivation of parallel fibresActivation of metabotropic glutamate receptorsActivation of AMPA receptorsActivation of climbing fibres

Question

Which of the following is NOT involved in the induction of long-term depression in Purkinje cells in the cerebellum?Group of answer choicesActivation of NMDA receptorsActivation of parallel fibresActivation of metabotropic glutamate receptorsActivation of AMPA receptorsActivation of climbing fibres

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Solution

The induction of long-term depression in Purkinje cells in the cerebellum does NOT involve the activation of NMDA receptors.

Here's a step-by-step explanation:

  1. Long-term depression (LTD) in the cerebellum is a process that decreases the efficiency of synaptic transmission, and it's a key mechanism for motor learning.

  2. The induction of LTD in Purkinje cells involves several steps. First, there is the simultaneous activation of parallel fibers and climbing fibers.

  3. The parallel fibers release glutamate, which binds to both metabotropic glutamate receptors (mGluRs) and AMPA receptors on the Purkinje cells.

  4. The activation of mGluRs leads to the production of a second messenger, which triggers a cascade of intracellular events.

  5. The activation of AMPA receptors allows the influx of sodium ions, which depolarizes the cell membrane.

  6. The climbing fibers also release glutamate, which binds to another type of glutamate receptor on the Purkinje cells.

  7. However, NMDA receptors, which are another type of glutamate receptor, are not involved in this process. In fact, Purkinje cells lack NMDA receptors. Therefore, the activation of NMDA receptors is not involved in the induction of LTD in Purkinje cells in the cerebellum.

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