) In arterial blood with a PO2 of 60 mmHg, which of the following situations will resultin the lowest blood oxygen saturation?a) decreased DPG with normal body temperature and blood pHb) increased body temperature, acidosis, and increased DPGc) decreased body temperature, alkalosis, and increased DPGd) normal body temperature with alkalosise) increased body temperature with alkalosis
Question
) In arterial blood with a PO2 of 60 mmHg, which of the following situations will resultin the lowest blood oxygen saturation?a) decreased DPG with normal body temperature and blood pHb) increased body temperature, acidosis, and increased DPGc) decreased body temperature, alkalosis, and increased DPGd) normal body temperature with alkalosise) increased body temperature with alkalosis
Solution
The oxygen saturation of blood is influenced by several factors, including the partial pressure of oxygen (PO2), 2,3-diphosphoglycerate (DPG) levels, body temperature, and blood pH.
a) Decreased DPG with normal body temperature and blood pH: DPG stabilizes the deoxygenated form of hemoglobin, promoting oxygen release. Therefore, decreased DPG would increase oxygen binding to hemoglobin, resulting in higher oxygen saturation.
b) Increased body temperature, acidosis, and increased DPG: Both increased body temperature and acidosis (lower pH) shift the oxygen-hemoglobin dissociation curve to the right, meaning that more oxygen is released from hemoglobin, resulting in lower oxygen saturation. Increased DPG also promotes oxygen release from hemoglobin, further lowering oxygen saturation.
c) Decreased body temperature, alkalosis, and increased DPG: Decreased body temperature and alkalosis (higher pH) shift the oxygen-hemoglobin dissociation curve to the left, meaning that less oxygen is released from hemoglobin, resulting in higher oxygen saturation. However, increased DPG promotes oxygen release from hemoglobin, which would lower oxygen saturation.
d) Normal body temperature with alkalosis: Alkalosis shifts the oxygen-hemoglobin dissociation curve to the left, meaning that less oxygen is released from hemoglobin, resulting in higher oxygen saturation.
e) Increased body temperature with alkalosis: Increased body temperature shifts the oxygen-hemoglobin dissociation curve to the right, meaning that more oxygen is released from hemoglobin, resulting in lower oxygen saturation. However, alkalosis shifts the curve to the left, which would increase oxygen saturation.
Therefore, the situation that will result in the lowest blood oxygen saturation is b) increased body temperature, acidosis, and increased DPG.
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