A cell makes a protein that it releases into the extracellular environment. Which best describes the sequence from synthesis to exocytosis? Golgi apparatus → rough endoplasmic reticulum → plasma membrane Nucleus → ribosome →smooth endoplasmic reticulum → plasma membrane Rough endoplasmic reticulum → Golgi apparatus → plasma membrane Rough endoplasmic reticulum → lysosome → plasma membrane Smooth endoplasmic reticulum → Golgi apparatus → plasma membrane
Question
A cell makes a protein that it releases into the extracellular environment. Which best describes the sequence from synthesis to exocytosis? Golgi apparatus → rough endoplasmic reticulum → plasma membrane Nucleus → ribosome →smooth endoplasmic reticulum → plasma membrane Rough endoplasmic reticulum → Golgi apparatus → plasma membrane Rough endoplasmic reticulum → lysosome → plasma membrane Smooth endoplasmic reticulum → Golgi apparatus → plasma membrane
Solution
The sequence that best describes the process from synthesis to exocytosis is: Rough endoplasmic reticulum → Golgi apparatus → plasma membrane.
Here's the step-by-step process:
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Synthesis: The process begins in the nucleus where the DNA is transcribed into mRNA. The mRNA then leaves the nucleus and goes to the ribosomes on the rough endoplasmic reticulum (RER). The ribosomes translate the mRNA into a protein.
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Processing: The newly synthesized protein then enters the RER, where it undergoes folding and modifications.
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Transport: The protein is then packaged into a transport vesicle, which buds off from the RER and moves towards the Golgi apparatus.
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Further Processing: In the Golgi apparatus, the protein undergoes further modifications and is sorted for transport to its final destination.
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Exocytosis: The protein is then packaged into a secretory vesicle that buds off from the Golgi apparatus. The secretory vesicle fuses with the plasma membrane and releases the protein into the extracellular environment. This process is known as exocytosis.
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