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An acidic drug is more soluble in stomach or small intestine?

Question

An acidic drug is more soluble in stomach or small intestine?

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Solution

An acidic drug is more soluble in the stomach. This is because the stomach has a highly acidic environment (with a pH around 1.5 to 3.5) due to the presence of hydrochloric acid. Acidic drugs (which are often weak acids) tend to remain non-ionized in this environment, which makes them more soluble and allows them to be absorbed more readily into the bloodstream.

On the other hand, the small intestine has a more neutral to slightly alkaline environment (with a pH around 6 to 7.4). In this environment, acidic drugs are more likely to become ionized, which makes them less soluble and less readily absorbed.

So, in summary, an acidic drug is more soluble in the stomach than in the small intestine due to the differences in pH.

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Cells that lower pH of stomach are

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