A young boy of African descent is taken to hospital with respiratory failure. His haemoglobin is 60 g/L.  Which of the following is the most likely diagnosis?Question 8Select one:a.Hb SS (sickle cell disease)b.beta thalassemia majorc.alpha thalassemiad.Hb C diseasee.Hb SA (sickle cell trait)

A young boy of African descent is taken to hospital with respiratory failure. His haemoglobin is 60 g/L and his blood film shows sickle cells. What would you expect to see on his CBC?Question 7Select one:a.high MCV and low RDWb.normal except low Hbc.high HCT and normal RDWd.low MCV and low RDWe.low HCT and high RDW

Which of the following two  statements correctly describes the behavior of the haemoglobin protein HbS in sickle-cell disease?Question 9Select one or more:a.The haemoglobin protein lacks a haem group.b.The haemoglobin protein dissociates into four subunits.c.Neighbouring haemoglobin proteins aggregate together.d.Caused by a change in the amino acid sequence in haemoglobin.e.The haemoglobin protein possesses an iron atom in the Fe (III) form rather than the normal Fe (II) form.f.Caused by a protein deficiency.

Which of the following describes sickle-cell disease? Multiple select question.Red blood cells take on a translucent appearance.It is a hereditary condition.The heme part of hemoglobin is abnormal.Red blood cells are misshapen.It can be caused by iron deficiency.

Hemoglobinopathies: Describe the mutation that causes Sickle Cell disease to affect the ability of Hb to function? Describe the mutation responsible for causing instability which affects the ability of Hb to function? Describe the mutation that causes Methemoglobin to affect the ability of Hb to function?

make 10 difficult MCQ questions with answers at the end based on this learning points Briefly describe each of the commonly occurring mutations of haemoglobin (thalassemia and sickle cell) and how these affect haemoglobin production and function.