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Which molecule serves as the primer for fatty acid synthesis?A) Acetyl-CoAB) Malonyl-CoAC) PalmitateD) Acyl carrier protein (ACP)

Question

Which molecule serves as the primer for fatty acid synthesis?A) Acetyl-CoAB) Malonyl-CoAC) PalmitateD) Acyl carrier protein (ACP)

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Solution

The molecule that serves as the primer for fatty acid synthesis is Acetyl-CoA (Option A).

Here's a step-by-step explanation:

  1. Fatty acid synthesis begins with the carboxylation of Acetyl-CoA to form Malonyl-CoA. This reaction is catalyzed by the enzyme Acetyl-CoA carboxylase.

  2. The Malonyl-CoA is then attached to the Acyl carrier protein (ACP), forming Malonyl-ACP.

  3. However, the initial primer for the synthesis is Acetyl-CoA, not Malonyl-CoA. This is because the first two carbons of the fatty acid chain come from Acetyl-CoA.

  4. The Acetyl group of Acetyl-CoA is transferred to the ACP, forming Acetyl-ACP.

  5. The Acetyl-ACP then reacts with Malonyl-ACP in a series of reactions to elongate the fatty acid chain.

  6. This process continues, with each cycle adding two carbons to the fatty acid chain, until the final product, Palmitate, is formed.

So, while Malonyl-CoA, ACP, and Palmitate are all involved in fatty acid synthesis, the primer for the process is Acetyl-CoA.

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