Which statement is correct regarding cyclin?Group of answer choicesPhosphorylation of the nuclear lamins by cyclin drives the disassembly of the nuclear envelope.Cyclin is activated by the repositioning of its T-loop after phosphorylation.CyclinE concentrations fluctuate multiple times during the cell cycle to regulate the different phases of division.Cancers can often develop due to mutations causing the overexpression of cyclin.
Question
Which statement is correct regarding cyclin?Group of answer choicesPhosphorylation of the nuclear lamins by cyclin drives the disassembly of the nuclear envelope.Cyclin is activated by the repositioning of its T-loop after phosphorylation.CyclinE concentrations fluctuate multiple times during the cell cycle to regulate the different phases of division.Cancers can often develop due to mutations causing the overexpression of cyclin.
Solution
The correct statement regarding cyclin is: "Cancers can often develop due to mutations causing the overexpression of cyclin."
Explanation: Cyclins are proteins that control the progression of cells through the cell cycle by activating cyclin-dependent kinase (CDK) enzymes. Overexpression of cyclins can lead to uncontrolled cell division, which is a characteristic of cancer.
The other statements are incorrect because:
- Phosphorylation of the nuclear lamins by cyclin does not drive the disassembly of the nuclear envelope. It's the CDK that phosphorylates nuclear lamins leading to the disassembly of the nuclear envelope.
- Cyclin itself is not activated by the repositioning of its T-loop after phosphorylation. It's the CDK that is activated this way.
- Cyclin E concentrations do not fluctuate multiple times during the cell cycle. Cyclin levels rise and fall once during each cell cycle.
Similar Questions
Which statement is correct regarding cyclin?Group of answer choicesIt phosphorylates CDK on Thr-160 to activate the CDK.Cyclin contains a destruction box sequence which is targeted by ubiquitin ligase.The activity of cyclin E is inhibited when bound by phosphorylated pRB.It is present at similar concentrations throughout the cell cycle.
What role does the proteasome play in the regulation of the cell cycle?Group of answer choicesIt degrades ubiquitinated cyclin as part of a positive CDK/cyclin feedback mechanism.It degrades ubiquitinated CDK as part of a negative CDK/cyclin feedback mechanism.It degrades ubiquitinated cyclin as part of a negative CDK/cyclin feedback mechanism.It degrades ubiquitinated CDK as part of a positive CDK/cyclin feedback mechanism.
An kinase enzyme that is active only when attached to a particular cyclin.Group of answer choicesMPFCdkcyclin
The role of ubiquitin in cell cycle control is to:Group of answer choicesstimulate cyclin synthesisdephosphorylate cyclindegrade cyclinphosphorylate cyclin
A cellular protein that occurs in a cyclically fluctuating concentration and that plays an important role in regulating the cell cycle.Group of answer choicesMPFCdkcyclin
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