Which series shows the order by which an antigenic sequence of amino acids is brought in contact with a T-cell receptor by a major histocompatibility complex (MHC)?A.Full-length protein → MHC I → MHC II → T-cell receptorB.Full-length protein → MHC II → MHC I → T-cell receptorC.Full-length protein → free digested protein fragments → MHC II → T-cell receptorD.Full-length protein → free digested protein fragments → MHC I → free digested protein fragments → T-cell receptorSubmit
Question
Which series shows the order by which an antigenic sequence of amino acids is brought in contact with a T-cell receptor by a major histocompatibility complex (MHC)?A.Full-length protein → MHC I → MHC II → T-cell receptorB.Full-length protein → MHC II → MHC I → T-cell receptorC.Full-length protein → free digested protein fragments → MHC II → T-cell receptorD.Full-length protein → free digested protein fragments → MHC I → free digested protein fragments → T-cell receptorSubmit
Solution
The correct order by which an antigenic sequence of amino acids is brought in contact with a T-cell receptor by a major histocompatibility complex (MHC) is:
Full-length protein → free digested protein fragments → MHC II → T-cell receptor
So, the correct answer is C.
Here's the step-by-step process:
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The full-length protein is first broken down into smaller pieces, or free digested protein fragments. This usually happens within a cell that the immune system has identified as a threat.
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These protein fragments are then loaded onto an MHC II molecule. MHC II molecules are found on the surface of antigen-presenting cells, like macrophages and B cells.
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The MHC II molecule, with the protein fragment, is then brought to the surface of the cell.
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A T-cell receptor on a T-helper cell then binds to the MHC II molecule and its protein fragment. This triggers the T cell to respond to the antigen.
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