Increasing the concentration of NADPH will inhibit which of the following enzymes?Group of answer choicesA. Glucose 6-phosphate dehydrogenaseB. LactonaseC. TransaldolaseD. EpimeraseE. All the above
Question
Increasing the concentration of NADPH will inhibit which of the following enzymes?Group of answer choicesA. Glucose 6-phosphate dehydrogenaseB. LactonaseC. TransaldolaseD. EpimeraseE. All the above
Solution
The enzyme that is inhibited by an increase in the concentration of NADPH is Glucose 6-phosphate dehydrogenase (A). This enzyme is part of the pentose phosphate pathway and its activity is regulated by the availability of NADP+. When NADPH concentration is high, it indicates that there is a sufficient supply of reducing power in the cell, thus the enzyme is inhibited to prevent unnecessary production of NADPH. The other enzymes listed (B. Lactonase, C. Transaldolase, D. Epimerase) are not directly affected by the concentration of NADPH.
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