Which of the following statements about reversible enzyme inhibitors areCORRECT?P. Uncompetitive inhibitors bind only to the enzyme-substrate complexQ. Non-competitive inhibitors bind only at a different site from thesubstrateR. Competitive inhibitors bind to the same site as the substrate(A) P and Q only(B) P and R only(C) Q and R only(D) P, Q and R
Question
Which of the following statements about reversible enzyme inhibitors areCORRECT?P. Uncompetitive inhibitors bind only to the enzyme-substrate complexQ. Non-competitive inhibitors bind only at a different site from thesubstrateR. Competitive inhibitors bind to the same site as the substrate(A) P and Q only(B) P and R only(C) Q and R only(D) P, Q and R
Solution
The correct answer is (D) P, Q and R.
Here's why:
P. Uncompetitive inhibitors bind only to the enzyme-substrate complex. This is correct. Uncompetitive inhibitors bind to the enzyme-substrate complex at a different site from the active site, locking them together. This inhibition increases with increased substrate concentration.
Q. Non-competitive inhibitors bind only at a different site from the substrate. This is also correct. Non-competitive inhibitors bind to an enzyme at a site other than its active site. This changes the shape of the enzyme and prevents it from binding to its substrate.
R. Competitive inhibitors bind to the same site as the substrate. This is correct as well. Competitive inhibitors compete with the substrate for the same active site, blocking its access.
So, all statements P, Q, and R are correct.
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