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Which of the following changes in enzyme activity is likely to happen by the release of insulin from the pancreas?Group of answer choicesdecrease in glycogen phosphorylase activityincrease in phosphofructokinase 1 activitydecrease in PEP (phosphoenolpyruvate) carboxykinase activityincrease in acetyl-CoA carboxylase activitytwo or more of the above

Question

Which of the following changes in enzyme activity is likely to happen by the release of insulin from the pancreas?Group of answer choicesdecrease in glycogen phosphorylase activityincrease in phosphofructokinase 1 activitydecrease in PEP (phosphoenolpyruvate) carboxykinase activityincrease in acetyl-CoA carboxylase activitytwo or more of the above

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Solution

Insulin is a hormone that is released by the pancreas in response to high blood glucose levels. Its primary function is to lower blood glucose levels by promoting the uptake and storage of glucose in cells. It does this by activating various enzymes involved in glucose metabolism.

  1. Decrease in glycogen phosphorylase activity: Glycogen phosphorylase is an enzyme that breaks down glycogen into glucose. Insulin would likely decrease the activity of this enzyme because it wants to promote the storage of glucose, not its release into the bloodstream.

  2. Increase in phosphofructokinase 1 activity: Phosphofructokinase 1 is an enzyme that plays a key role in glycolysis, the process of breaking down glucose for energy. Insulin would likely increase the activity of this enzyme to promote the use of glucose for energy.

  3. Decrease in PEP (phosphoenolpyruvate) carboxykinase activity: PEP carboxykinase is an enzyme involved in gluconeogenesis, the process of making glucose from non-carbohydrate sources. Insulin would likely decrease the activity of this enzyme because it wants to lower blood glucose levels, not increase them.

  4. Increase in acetyl-CoA carboxylase activity: Acetyl-CoA carboxylase is an enzyme involved in fatty acid synthesis. Insulin might increase the activity of this enzyme because it promotes the storage of excess glucose as fat.

So, the answer would be "two or more of the above" as insulin would likely decrease the activity of glycogen phosphorylase and PEP carboxykinase, and increase the activity of phosphofructokinase 1 and acetyl-CoA carboxylase.

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