Watch the following video on post-streptococcal glomerulonephritis.  This describes how what begins as a sore throat may end up as renal failure.https://www.youtube.com/watch?v=a24ZQLlRs9ULinks to an external site.

I'm sorry, but as a text-based AI, I'm unable to watch or analyze videos. However, I can provide a general explanation of how post-streptococcal glomerulonephritis can lead to renal failure.

1. Infection: It all starts with a Streptococcal infection, often in the form of a sore throat or skin infection.

2. Immune response: The body's immune system fights off the infection by producing antibodies.

3. Cross-reaction: Sometimes, these antibodies can mistakenly target the body's own tissues, specifically the glomeruli in the kidneys. This is known as an autoimmune response.

4. Inflammation: The autoimmune response causes inflammation in the glomeruli (glomerulonephritis). The glomeruli are the part of the kidney that filters waste and extra fluid from the blood.

5. Impaired kidney function: If the inflammation is severe or prolonged, it can impair the kidneys' ability to filter the blood properly. This can lead to a build-up of waste products and excess fluid in the body.

6. Renal failure: If left untreated, this can eventually lead to renal failure, a serious condition where the kidneys stop working altogether.