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18. The following is the guardian of the genome: a. TP53 gene. B. RB gene. c. Bcl2 gene. d. MYC gene. 19. The following are groups of oncogenes EXCEPT: a. Genes Which produce growth factors. b. Genes which produce the growth factor receptors. c. Genes which encode signal transduction. d. Genes which encode products stop cell proliferation. 20. Disordered proliferation of cells is known as: A. Metaplasia. b. Hyperplasia. c. Dysplasia. d. Atrophy. 21. Squamous metaplasia does not occur in the following site: a. Bronchial epithelium in cigarette smokers. b. Gall bladder due to gall stones. C. Lower end of esophagus. d. Urinary bladder epithelium in association with Bilharziasis. 22. Which of the following is FALSE about malignant cachexia: a. Marked weakness and anemia. b. Marked decrease of body fat and lean body mass. c. Cachexia results due to nutritional demands of the tumor. d. Cachexia results from action of cytokines produced by tumor and host macrophages. 23. Normal cellular genes that encode proteins that drive cell proliferation are: a. Proto-oncogenes. b. Oncogenes. c. Tumor suppressor genes. d. Apoptotic genes. 24. Leukoplakia is defined as: a. Transformation of columnar epithelium into squamous. b. Squamous epithelium keratinization. c. Carcinoma in situ of squamous epithelium. d. Benign epithelial tumor. 25.As regard the histological differentiation of malignant tumors a. Anaplastic cells show normal polarity. b. Anaplastic cells show cytologic abnormalities. c. Sarcomas may be graded as well differentiated, moderately differentiated, poorly differentiated & undifferentiated. d. Better differentiated tumors tend to show great cellular anaplasia & grow faster. 26. Embryonic Tumors include the following EXCEPT. a. Neuroblastoma. b. Retinoblastoma. C. Nephroblastoma. d. Choriocarcinoma. 27. Immunohistochemical study of squamous cell carcinoma show strong expression of which of the following tumor markers: a. Vimentin. b. Cytokeratin. c. Alpha feto-protein. d. Calcitonin. 28. The following is a characteristic of carcinoma in situ: architectural orientation (polarity) is not disturbed. a. The b. There is invasion of basement membrane. c. It is a benign condition. d. There is full thickness cellular atypia. 29. Hypertrophy is: a. Disordered atypical non-neoplastic cellular proliferation. b. Increase in the size of the cells. c. Uncontrolled autonomous cell growth d. Increase in the number of the cells. 30. Metaplasia may be a precancerous condition in all EXCEPT: a. Squamous metaplasia of the urinary bladder epithelium. b. Squamous metaplasia of the bronchial epithelium. c. Intestinal metaplasia of the gastric mucosa. d. Apocrine metaplasia in fibrocystic disease of the breast.

Question

  1. The following is the guardian of the genome:

a. TP53 gene.

B. RB gene.

c. Bcl2 gene.

d. MYC gene.

  1. The following are groups of oncogenes EXCEPT:

a. Genes Which produce growth factors.

b. Genes which produce the growth factor receptors.

c. Genes which encode signal transduction.

d. Genes which encode products stop cell proliferation.

  1. Disordered proliferation of cells is known as:

A. Metaplasia.

b. Hyperplasia.

c. Dysplasia.

d. Atrophy.

  1. Squamous metaplasia does not occur in the following site:

a. Bronchial epithelium in cigarette smokers.

b. Gall bladder due to gall stones.

C. Lower end of esophagus.

d. Urinary bladder epithelium in association with Bilharziasis.

  1. Which of the following is FALSE about malignant cachexia:

a. Marked weakness and anemia.

b. Marked decrease of body fat and lean body mass.

c. Cachexia results due to nutritional demands of the tumor.

d. Cachexia results from action of cytokines produced by tumor and host macrophages.

  1. Normal cellular genes that encode proteins that drive cell proliferation are:

a. Proto-oncogenes.

b. Oncogenes.

c. Tumor suppressor genes.

d. Apoptotic genes.

  1. Leukoplakia is defined as:

a. Transformation of columnar epithelium into squamous.

b. Squamous epithelium keratinization.

c. Carcinoma in situ of squamous epithelium.

d. Benign epithelial tumor.

25.As regard the histological differentiation of malignant tumors

a. Anaplastic cells show normal polarity.

b. Anaplastic cells show cytologic abnormalities.

c. Sarcomas may be graded as well differentiated, moderately differentiated, poorly differentiated & undifferentiated.

d. Better differentiated tumors tend to show great cellular anaplasia & grow faster.

  1. Embryonic Tumors include the following EXCEPT.

a. Neuroblastoma.

b. Retinoblastoma.

C. Nephroblastoma.

d. Choriocarcinoma.

  1. Immunohistochemical study of squamous cell carcinoma show strong expression of which of the following tumor markers:

a. Vimentin.

b. Cytokeratin.

c. Alpha feto-protein.

d. Calcitonin.

  1. The following is a characteristic of carcinoma in situ: architectural orientation (polarity) is not disturbed.

a. The

b. There is invasion of basement membrane.

c. It is a benign condition.

d. There is full thickness cellular atypia.

  1. Hypertrophy is:

a. Disordered atypical non-neoplastic cellular proliferation.

b. Increase in the size of the cells.

c. Uncontrolled autonomous cell growth

d. Increase in the number of the cells.

  1. Metaplasia may be a precancerous condition in all EXCEPT:

a. Squamous metaplasia of the urinary bladder epithelium.

b. Squamous metaplasia of the bronchial epithelium.

c. Intestinal metaplasia of the gastric mucosa.

d. Apocrine metaplasia in fibrocystic disease of the breast.

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Solution

Sure, here are the answers to your questions:

  1. a. TP53 gene.

  2. d. Genes which encode products stop cell proliferation.

  3. b. Hyperplasia.

  4. b. Gall bladder due to gall stones.

  5. c. Cachexia results due to nutritional demands of the tumor.

  6. a. Proto-oncogenes.

  7. b. Squamous epithelium keratinization.

  8. b. Anaplastic cells show cytologic abnormalities.

  9. d. Choriocarcinoma.

  10. b. Cytokeratin.

  11. d. There is full thickness cellular atypia.

  12. b. Increase in the size of the cells.

  13. d. Apocrine metaplasia in fibrocystic disease of the breast.

This problem has been solved

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