PharmacokineticsAbsorption >Distribution (blood/plasma): o(Storage) << Bound drug..…Free drug (will go to the)>> Cell receptorMetabolism EliminationBlood / Plasma:oBound drug (released to become) >>>> Free drug (go towards) >> Cell receptoro <<<<oInactive & ActiveoEquilibrium is maintainedoAs level of free drug decreases, some bound drugs are released.
Question
PharmacokineticsAbsorption >Distribution (blood/plasma): o(Storage) << Bound drug..…Free drug (will go to the)>> Cell receptorMetabolism EliminationBlood / Plasma:oBound drug (released to become) >>>> Free drug (go towards) >> Cell receptoro <<<<oInactive & ActiveoEquilibrium is maintainedoAs level of free drug decreases, some bound drugs are released.
Solution
Pharmacokinetics is the study of how drugs are absorbed, distributed, metabolized, and eliminated by the body. Let's break down each step:
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Absorption: This is the process by which a drug enters the bloodstream from its site of administration. It is important to note that not all of the drug may be absorbed, as some may be lost or metabolized before reaching the bloodstream.
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Distribution: Once in the bloodstream, the drug can be distributed throughout the body. It can either be bound to proteins in the blood or exist in a free, unbound form. The free drug is the active form that can interact with cell receptors and produce the desired effect.
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Metabolism: The body metabolizes drugs to convert them into inactive or active metabolites. This process occurs mainly in the liver, where enzymes break down the drug into smaller molecules. Some drugs may become more active after metabolism, while others may become less active or even inactive.
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Elimination: The body eliminates drugs through various routes, such as urine, feces, sweat, and breath. The primary organ responsible for drug elimination is the kidneys, which filter the drug from the blood and excrete it in the urine. Other organs, such as the liver and lungs, also play a role in drug elimination.
In the blood or plasma, the drug can exist in two forms: bound and free. Bound drugs are attached to proteins and are not able to interact with cell receptors. However, as the level of free drug decreases, some bound drugs may be released and become free, allowing them to reach the cell receptors and produce the desired effect.
Overall, pharmacokinetics helps us understand how drugs are processed by the body, which is crucial for determining the appropriate dosage and frequency of administration to achieve the desired therapeutic effect.
Similar Questions
The plasma protein binding of the drug is characterized by:A. The protein-bound drugs are distributed and metabolizedB. The unbound fraction of the drug is activeC. Bound form is eliminated by the kidney more than free formD. Increased binding to plasma protein will increase drug distribution
What are the four processes of pharmacokinetics? Question 1 options: A) Distribution, metabolism, excretion, and hydration B) Metabolism, excretion, synthesis, and absorption C) Absorption, distribution, hydration, and synthesis D) Absorption, distribution, metabolism, and excretion Question 2 (5 points) What is the term for the theoretical concept that a drug would have all good effects and qualities and no negative effects or qualities? Question 2 options: A) Desired effect B) Ideal drug C) Pharmacodynamics D) Margin of safety Question 3 (5 points) Which of the following affect(s) the distribution of a drug? Question 3 options: A) The rate of metabolism B) Fat solubility and protein-binding ability C) The functioning of the liver and kidneys D) Excretory functions Question 4 (5 points) What is the margin of safety? Question 4 options: A) The effect of a drug on the whole body B) The difference between the therapeutic dose and the toxic dose C) The expected response that occurs from drug administration D) A predictable but not desired response Question 5 (5 points) Which of the following is not a drug source? Question 5 options: A) Animals B) Minerals C) Metabolism D) Synthetic sources Question 6 (5 points) A drug used to counteract the effect of an excessive drug toxicity level is called a/an Question 6 options: A) legend drug. B) safe drug. C) antidote. D) anti-inflammatory drug. Question 7 (5 points) What is a contraindication? Question 7 options: A) A predictable but not desired response B) The difference between the therapeutic dose and the toxic dose C) A condition in which the use of a specific medication should be avoided D) A chemical used for therapeutic purposes Question 8 (5 points) Which of the following statements is true concerning physician prescription pads? Question 8 options: A) Prescription pads don't need to be kept in a locked drawer or cabinet when not being used. B) Prescription pads should be left in the examination rooms. C) Prescription pads aren't used much anymore. D) Many offices primarily enter prescriptions electronically. Question 9 (5 points) Which route is considered to be the fastest way of getting drugs into the bloodstream? Question 9 options: A) Percutaneous B) Buccal C) Oral D) Parenteral Question 10 (5 points) Which of the following choices contain the primary sites of absorption? Question 10 options: A) Lungs, blood vessels in muscle tissue, and spleen B) Pancreas, spleen, and stomach C) Stomach, mucosa of the mouth, and lungs D) Subcutaneous tissue, lungs, and pancreas
Distribution: Tissue Binding and StorageE.g. Usually with albumin a plasma protein and sometimes with fat tissueoOnly free or unbound drug molecules can act on a receptoro‘bound’ drug is unable to bind with a cell receptor so cannot actHow is drug binding and storage significant in drug therapy?
Receptor is:a.Enzymes of oxidizing-reducing reactions activated by a drugb.All types of ion channels modulated by a drugc.Carriers activated by a drugd.Active macromolecule of a cell which a drug molecule has to combine withClear my choice
AbsorptionDrug moves from site of administration into the blood, crossing at least one membrane (except if administered IV)To cross membranes, drugs must be in solution and lipid solubleInfluenced by..oRoute of administrationoDosage form – solution, tablet, suppository, etc.oSolubility of the drug – if lipid soluble, drugs cross membranes more easilyoOther factors – food in stomach, type of food in stomach; movement of drug through stomach and small intestine, pH of stomach/intestinal fluids, etc.First-pass effect – influences bioavailability of the drugBioavailability of the drug - “portion of a [drug] dose that reaches systemic circulation and is available to act on body cells
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