A. The protein-bound drugs are distributed and metabolized: This is true. Drugs that are bound to plasma proteins can be distributed throughout the body and metabolized. However, it's important to note that while the drug is bound to the protein, it is not active.

B. The unbound fraction of the drug is active: This is also true. Only the unbound (free) fraction of a drug is able to exert a pharmacological effect. The protein-bound fraction is essentially a reservoir for the drug, but while the drug is bound, it is not active.

C. Bound form is eliminated by the kidney more than free form: This is false. The kidneys filter out small molecules, which includes unbound drugs. Protein-bound drugs are too large to be filtered by the kidneys, so they remain in the bloodstream until they are released from the protein.

D. Increased binding to plasma protein will increase drug distribution: This is false. Increased binding to plasma proteins will decrease drug distribution. This is because only the unbound fraction of a drug can diffuse across cell membranes and reach its site of action. If a drug is highly bound to plasma proteins, less of the drug is available to exert a pharmacological effect.

Question

A. The protein-bound drugs are distributed and metabolized: This is true. Drugs that are bound to plasma proteins can be distributed throughout the body and metabolized. However, it's important to note that while the drug is bound to the protein, it is not active.

B. The unbound fraction of the drug is active: This is also true. Only the unbound (free) fraction of a drug is able to exert a pharmacological effect. The protein-bound fraction is essentially a reservoir for the drug, but while the drug is bound, it is not active.

C. Bound form is eliminated by the kidney more than free form: This is false. The kidneys filter out small molecules, which includes unbound drugs. Protein-bound drugs are too large to be filtered by the kidneys, so they remain in the bloodstream until they are released from the protein.

D. Increased binding to plasma protein will increase drug distribution: This is false. Increased binding to plasma proteins will decrease drug distribution. This is because only the unbound fraction of a drug can diffuse across cell membranes and reach its site of action. If a drug is highly bound to plasma proteins, less of the drug is available to exert a pharmacological effect.

Knowee AI · Accepted Answer

A. The protein-bound drugs are distributed and metabolized: This is true. Drugs that are bound to plasma proteins can be distributed throughout the body and metabolized. However, it's important to note that while the drug is bound to the protein, it is not active.

B. The unbound fraction of the drug is active: This is also true. Only the unbound (free) fraction of a drug is able to exert a pharmacological effect. The protein-bound fraction is essentially a reservoir for the drug, but while the drug is bound, it is not active.

C. Bound form is eliminated by the kidney more than free form: This is false. The kidneys filter out small molecules, which includes unbound drugs. Protein-bound drugs are too large to be filtered by the kidneys, so they remain in the bloodstream until they are released from the protein.

D. Increased binding to plasma protein will increase drug distribution: This is false. Increased binding to plasma proteins will decrease drug distribution. This is because only the unbound fraction of a drug can diffuse across cell membranes and reach its site of action. If a drug is highly bound to plasma proteins, less of the drug is available to exert a pharmacological effect.

The plasma protein binding of the drug is characterized by:A. The protein-bound drugs are distributed and metabolizedB. The unbound fraction of the drug is activeC. Bound form is eliminated by the kidney more than free formD. Increased binding to plasma protein will increase drug distribution

Question

Solution

Similar Questions

Upgrade your grade with Knowee