Week 5 Moodle LessonMIC3011 S1 2024Week 5 Moodle LessonCompletion requirements DONE: GO THROUGH THE ACTIVITY TO THE ENDThis Moodle lesson will take you through the lecture content for Week 5.The conserved domains common to all two-component system sensor histidine kinases are, in order from N- to C-terminus: a transmembrane sensor domain, a dimerization and histidine phosphorylation domain, a catalytic ATPase domain, and a receiver domain.a transmembrane sensor domain, a catalytic ATPase domain, a dimerization and histidine phosphorylation domain, and a receiver domain.a transmembrane sensor domain, a catalytic ATPase domain, and a dimerization and histidine phosphorylation domain.a transmembrane sensor domain, a dimerization and histidine phosphorylation domain, and a catalytic ATPase domain.

The phosphorelay controlling sporulation in Bacillus subtilis integrates signals from five different sensor histidine kinases and transmits these through two phosphorelay proteins before phosphorylation and activation of the response regulator. This type of organisation:is an example of regulatory cross-talk between different two-component systems.allows for additional regulation by specific phosphatases which act on the response regulator.allows for additional regulation by specific phosphatases which act on the phosphorelay proteins.allows for additional regulation by hybrid sensor histidine kinases, which act on the response regulator.

Design features of kinase inhibitors

Which of the following membrane receptors act as dimers that result in protein phosphorylation reactions following ligand binding?Group of answer choicesAdhesion receptorsReceptor tyrosine kinasesG protein-coupled receptorsLigand gated ion channels

Which of the following membrane receptors act as dimers that result in protein phosphorylation reactions following ligand binding?Group of answer choicesLigand gated ion channelsAdhesion receptorsReceptor tyrosine kinasesG protein-coupled receptors

extracellular ligand-binding domain, a single transmembrane helix, and an intracellular domain with kinase activity or one that associates with kinases.