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Which one of the following statements about volume of distribution is correct?Group of answer choicesIt is generally large for drugs that bind extensively to plasma proteins.It is large for drugs that are ion trapped into tissues.It is generally small for drugs that are lipid soluble.It is generally small for drugs that bind extensively to tissues, such as muscle and fat.

Question

Which one of the following statements about volume of distribution is correct?Group of answer choicesIt is generally large for drugs that bind extensively to plasma proteins.It is large for drugs that are ion trapped into tissues.It is generally small for drugs that are lipid soluble.It is generally small for drugs that bind extensively to tissues, such as muscle and fat.

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Solution

The correct statement is: "It is large for drugs that are ion trapped into tissues."

Explanation: The volume of distribution (Vd) is a theoretical volume that a drug would have to occupy to provide the same concentration as it does in the blood. If a drug is ion trapped into tissues, it means that the drug has moved from the bloodstream into the tissues and has become trapped there due to changes in pH. This would increase the apparent volume of distribution because the drug is not just in the bloodstream, but also distributed in the tissues.

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