What is the anticipated effect of drug volume of distribution in older patients who have increased body fat?Group of answer choicesDecreased volume of distribution for highly lipophilic drugsNo answers are correctIncreased volume of distribution for highly lipophilic drugsIncreased volume of distribution of water soluble drugs

Which one of the following statements about volume of distribution is correct?Group of answer choicesIt is generally large for drugs that bind extensively to plasma proteins.It is large for drugs that are ion trapped into tissues.It is generally small for drugs that are lipid soluble.It is generally small for drugs that bind extensively to tissues, such as muscle and fat.

Excretion rates of drugs vary greatly depending upon__________________.The age and weight of the personThe type of drug involved and medical condition of the personHow much of the drug was takenThe type of drug and length of time since it was ingested

Distribution: Tissue Binding and StorageE.g. Usually with albumin a plasma protein and sometimes with fat tissueoOnly free or unbound drug molecules can act on a receptoro‘bound’ drug is unable to bind with a cell receptor so cannot actHow is drug binding and storage significant in drug therapy?

Older adults have a higher risk of adverse drug events compared with younger people because of higher blood levels.  Which of the following can lead to increased blood levels of medication with aging?Group of answer choicesKidney function declinesAbsorption of medication is increased through the stomachLiver enzymes are more activeAll of the above

Select all that applyWhich of the following are methods to estimate body fat percentages?Multiple select question.skinfold measurementelectroencephalographyblood teststress testunderwater weighing