All of the following statements concerning CK-MB (CK-2) are true EXCEPT:Please select the single best answer Greater than 5% or 10 IU/L followed by an LDH-1: LDH-2 flip is specific evidence of myocardial infarction (MD). CK-MB levels can be normal with an elevated total CK. CK-MB and troponin levels can be elevated after an AMI. CK-MB levels are normal in cardiac ischemia
Question
All of the following statements concerning CK-MB (CK-2) are true EXCEPT:Please select the single best answer Greater than 5% or 10 IU/L followed by an LDH-1: LDH-2 flip is specific evidence of myocardial infarction (MD). CK-MB levels can be normal with an elevated total CK. CK-MB and troponin levels can be elevated after an AMI. CK-MB levels are normal in cardiac ischemia
Solution
The statement that is NOT true concerning CK-MB (CK-2) is: "Greater than 5% or 10 IU/L followed by an LDH-1: LDH-2 flip is specific evidence of myocardial infarction (MD)."
This statement is not accurate because the LDH-1: LDH-2 flip is no longer used as a specific marker for myocardial infarction. While it is true that LDH levels can increase after a heart attack, the ratio of LDH-1 to LDH-2 (the so-called "flip") is not a reliable or specific indicator of a heart attack.
The other statements are true:
- CK-MB levels can be normal even if the total CK level is elevated, because CK-MB is a specific type of creatine kinase that is found mostly in the heart muscle.
- Both CK-MB and troponin levels can be elevated after an acute myocardial infarction (AMI).
- CK-MB levels are typically normal in cardiac ischemia because ischemia does not cause significant damage to heart muscle cells.
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