In Sickle-Cell disease is caused by a mutation in a gene that codes for one of the protein's subunits. Which one of the following statements about this disease is correct?Group of answer choicesThe mutation is due to a silent mutation within the alpha subunit that changes an electrically charged amino acid to another electrically charged amino acid.acid.The mutation is due to a missense mutation within the beta subunit that changes an electrically charged amino acid to a nonpolar amino acid.The mutation is due to a missense mutation within the alpha subunit that changes an electrically charged amino acid to a nonpolar amino acid.The mutation is due to a silent mutation within the beta subunit that changes an electrically charged amino acid to another electrically charged amino.
Question
In Sickle-Cell disease is caused by a mutation in a gene that codes for one of the protein's subunits. Which one of the following statements about this disease is correct?Group of answer choicesThe mutation is due to a silent mutation within the alpha subunit that changes an electrically charged amino acid to another electrically charged amino acid.acid.The mutation is due to a missense mutation within the beta subunit that changes an electrically charged amino acid to a nonpolar amino acid.The mutation is due to a missense mutation within the alpha subunit that changes an electrically charged amino acid to a nonpolar amino acid.The mutation is due to a silent mutation within the beta subunit that changes an electrically charged amino acid to another electrically charged amino.
Solution
The correct statement about Sickle-Cell disease is: "The mutation is due to a missense mutation within the beta subunit that changes an electrically charged amino acid to a nonpolar amino acid."
Here's why:
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Sickle-Cell disease is caused by a mutation in the HBB gene, which codes for the beta subunit of hemoglobin.
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This mutation is a missense mutation, which means that it results in a different amino acid being incorporated into the protein. In this case, the mutation changes the sixth amino acid from glutamic acid, which is electrically charged, to valine, which is nonpolar.
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Silent mutations do not change the amino acid sequence of the protein, so they cannot be responsible for Sickle-Cell disease.
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The mutation occurs in the beta subunit, not the alpha subunit.
Similar Questions
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