A 27‐year‐old woman presents to her general practitioner with fatigue and easy bruising. A full blood count shows pancytopenia, and she is admitted to the hospital. The partial thromboplastin and prothrombin time (international normalized ratio) are both abnormal, and fragmented red cells are noted on blood film. Which ONE of the following is the most likely diagnosis in this case? A Acute lymphoblastic leukaemia B Acute promyelocytic leukaemia C Acute monoblastic leukaemia D Acute myeloid leukaemia without differentiation
Question
A 27‐year‐old woman presents to her general practitioner with fatigue and easy bruising. A full blood count shows pancytopenia, and she is admitted to the hospital. The partial thromboplastin and prothrombin time (international normalized ratio) are both abnormal, and fragmented red cells are noted on blood film. Which ONE of the following is the most likely diagnosis in this case? A Acute lymphoblastic leukaemia B Acute promyelocytic leukaemia C Acute monoblastic leukaemia D Acute myeloid leukaemia without differentiation
Solution
The symptoms described, including fatigue, easy bruising, pancytopenia, abnormal partial thromboplastin and prothrombin time, and fragmented red cells on blood film, are indicative of a condition known as Thrombotic Thrombocytopenic Purpura (TTP). However, this option is not listed among the choices provided.
Among the given options, Acute Promyelocytic Leukaemia (APL) is the most likely diagnosis. APL is a subtype of Acute Myeloid Leukaemia characterized by a deficiency of mature blood cells in the blood and an excess of immature cells in the bone marrow. Symptoms often include fatigue, easy bruising and bleeding, which aligns with the patient's presentation.
However, it's important to note that definitive diagnosis would require further tests, such as bone marrow biopsy and genetic studies.
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