Which of the following statements is (are) trueabout the G-protein coupled receptors (GPCRs)?A.There are only a few GPCRs in the human genome.B.When a signal molecule binds to the GPCR it causesphosphorylation of the GPCR that allows the G-proteinto bind.C.GPCRs act as GEFs for specific G-proteins.D.They are peripheral proteins composed of multiplepolypeptides.

When a ligand binds to a GPCR, what happens to the G-protein associated with the receptor?Question 11Answera.The β subunit activates adneylyl cyclase.b.The G-protein dissociates into its α and βγ subunits.c.The G-protein binds ATP.d.The G-protein is internalised by the cell.

Which one of the following statements about µ-opioid receptors is INCORRECT?Group of answer choicesThey are Gi-coupled G protein-coupled receptors (GPCRs).Antagonists of µ-opioid receptors are useful analgesic agents.The brain and spinal cord are densely populated with µ-opioid receptors.µ-opioid receptors are found in gastrointestinal tissues.

Which of the following is NOT a pattern recognition receptor?Select one alternative:G-protein-coupled receptorRIG-like receptorNOD-like receptorToll-like receptor

G protein coupled receptor pathway of cell signalling

Which of the following statements applies to G proteins?Group of answer choicesG proteins do not use second messengers, but transmit signals directly into the nucleusG proteins are dimeric, composed of two different subunitsG proteins transmit a signal from the interior of the cell to the cell surfaceG proteins act to amplify a signal creating a cascade response in the cell