Which one of the following statements about µ-opioid receptors is INCORRECT?Group of answer choicesThey are Gi-coupled G protein-coupled receptors (GPCRs).Antagonists of µ-opioid receptors are useful analgesic agents.The brain and spinal cord are densely populated with µ-opioid receptors.µ-opioid receptors are found in gastrointestinal tissues.

Which of the following statements is (are) trueabout the G-protein coupled receptors (GPCRs)?A.There are only a few GPCRs in the human genome.B.When a signal molecule binds to the GPCR it causesphosphorylation of the GPCR that allows the G-proteinto bind.C.GPCRs act as GEFs for specific G-proteins.D.They are peripheral proteins composed of multiplepolypeptides.

Receptors of opioids are present in :-A CNS B Spleen C GIT D Both (1) and (3)

Which of the following is NOT a pattern recognition receptor?Select one alternative:G-protein-coupled receptorRIG-like receptorNOD-like receptorToll-like receptor

Which of the following receptors is correctly identified asan ionotropic or a GPCR and correctly paired with the ionicchanges and/or second messenger induced by the binding of anagonist?A. 5-HT1A receptors are GPCRs whose activation increases IP3and DAG and increases K+ conduction.B. Nicotinic receptors are ionotropic receptors whose activationdecreases Na+ and K+ conduction.C. GABAA receptors are GPCRs whose activation increasescAMP and decreases K+ conduction.D. NMDA receptors are ionotropic receptors whose activationincreases Na+, K+, and Ca2+ conductance.E. Glycine receptors are GPCRs whose activation increases IP3and DAG and increases K+ conductance

Which one of the following statements regarding drug action in the central nervous system (CNS) is INCORRECT?Group of answer choicesG protein-coupled receptors can modulate ion-channel activity in the CNS.Glycine acts as an excitatory neurotransmitter in the CNS.Drugs can modulate the actions of both pre- and post-junctional receptors in the CNS.GABA acts as an inhibitory neurotransmitter in the CNS.