A 29-year-old man is diagnosed with testicular cancer and undergoes orchiectomy. He is followed afterward, and the cancer recurs. He elects to undergo treatment with bleomycin, etoposide, and cisplatin for four cycles. Several months after finishing chemotherapy, he returns for follow-up. On examination, he has bilateral dry crackles over both lung fields. His laboratory values are significant for a hemoglobin of 9.4 g/dL and a creatinine of 2.4 mg/dL (baseline 1.1 mg/dL). Which of the following is most likely responsible for the lung findings on examination?Ask StudybuddyGroup of answer choicesCisplatinBleomycinEtoposideTumor metastases

A 9-year-old girl being treated with combination chemotherapy for acute lymphoblastic leukemia (ALL) is noted to have increased levels of blood urea nitrogen (BUN) and creatinine on day 4 of treatment. The patient is immediately started on intravenous normal saline. An ECG is ordered which demonstrates prolonged QT intervals. For confirmation of the diagnosis, several laboratory tests, including a complete metabolic profile, are ordered. Which of the following laboratory abnormalities result from this patient's condition?

A 9-year-old girl being treated with combination chemotherapy for acute lymphoblastic leukemia (ALL) is noted to have increased levels of blood urea nitrogen (BUN) and creatinine on day 4 of treatment. The patient is immediately started on intravenous normal saline. An ECG is ordered which demonstrates prolonged QT intervals. For confirmation of the diagnosis, several laboratory tests, including a complete metabolic profile, are ordered. Which of the following laboratory abnormalities result from this patient's condition?Ask StudybuddyGroup of answer choicesDecreased calcium, increased phosphate, decreased uric acid, decreased potassiumDecreased calcium, decreased phosphate, increased uric acid, increased potassiumDecreased calcium, increased phosphate, increased uric acid, increased potassiumIncreased calcium, increased phosphate, increased potassium, increased uric acid

A 72-year-old man just returned from the cancer clinic after receiving the first dose of chemotherapy against lung cancer. His blood biochemical results are:Analyte (SERUM)ResultReference intervalSodium124135 – 145 mmol/LPotassium3.83.5 – 5.5 mmol/LChloride9095 – 110 mmol/LBicarbonate2522 – 32 mmol/LUrea3.63.0 – 8.0 mmol/LCreatinine4740 – 90 μmol/LHow would you explain his low sodium result? Predict his urine osmolality.Group of answer choicesSyndrome of inappropriate ADH (siADH); low urine osmolalityTumour lysis syndrome; low urine osmolalityTumour lysis syndrome; high urine osmolalitySyndrome of inappropriate ADH (siADH); high urine osmolali

A 68-year-old male with a history of lung cancer undergoes follow-up labs after recent cycle of chemotherapy. He has mild difficulty with concentration over the past week but is otherwise able to complete all of his daily tasks. He reports no nausea, vomiting, or positional lightheadedness. He has no other significant past medical history. He takes no medications. Vital signs are as follows: Temperature 99.8°F, RR 18, BP 135/88 mm Hg, pulse 76. On examination, he is alert and oriented. Cardiac examination reveals regular rate and rhythm, no murmurs, JVP not elevated. Lung and abdominal examinations are normal. There is no lower extremity edema. Skin turgor is normal. Neurologic examination reveals 5/5 strength in all extremities, no focal deficits, and normal gait. Laboratory tests reveal the following: serum Na+ 121 mEq/L, K+ 4.3 mEq/L, BUN 7.0 mg/dL, Cr 0.4 mg/dL, glucose 106 mg/dL. TSH 2.0 mU/L. Serum osmolality 250 mOsm/kg, urine Na 45 mEq/L, urine osmolality 450 mOsm/kg. What is the most appropriate management of this patient?

Suggest how chemotherapy may sometimes be ineffective at killing leukaemia cells.