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Bonus question: Can anyone explain how the shape of red blood cells differs in people with sickle cell anemia? What complications does this cause?

Question

Bonus question: Can anyone explain how the shape of red blood cells differs in people with sickle cell anemia? What complications does this cause?

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Solution

Sure, I'd be happy to explain.

  1. Normal Red Blood Cells: Typically, red blood cells are round and flexible with a donut-like shape, minus the hole in the center. This shape allows them to move easily through the blood vessels, including the smallest capillaries.

  2. Sickle Cell Anemia: In people with sickle cell anemia, the red blood cells become rigid and sticky. They are shaped like sickles or crescent moons. This abnormal shape is due to a mutation in the gene that produces hemoglobin, the protein in red blood cells that carries oxygen.

  3. Complications: The sickle-shaped cells can get stuck in small blood vessels, which can slow or block blood flow and oxygen to parts of the body. This can cause pain and tissue damage. In addition, because sickle cells don't last as long as normal red blood cells, they can cause anemia, a condition in which there aren't enough red blood cells to carry adequate oxygen to the body's tissues. Other complications can include infections, delayed growth, and vision problems.

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Similar Questions

Which of the following describes sickle-cell disease? Multiple select question.Red blood cells take on a translucent appearance.It is a hereditary condition.The heme part of hemoglobin is abnormal.Red blood cells are misshapen.It can be caused by iron deficiency.

Consider the genetic condition known as "Sickle Cell Disease."Healthy Red Blood Cells (left) and Red Blood Cells in an Individual with Sickle Cell Anemia (right) by Jack Potte (CC0)Most people have oval-shaped red blood cells. At some point in time, a mutation happened within the human genetic code, causing some people to have crescent-shaped blood cells (sickle cells).In terms of genotypes, someone who is homozygous dominant (AA) has oval-shaped red blood cells, and someone who is homozygous recessive (SS) has crescent-shaped blood cells. Someone who is heterozygous (AS) has a mixture of oval- and crescent-shaped blood cells.How did the mutation in the genetic code directly lead to a change blood cell shape?Elimination ToolSelect one answerAThe change in DNA changed the cell's instructions for making certain carbohydrates, which impacted blood cell shape.BThe change in DNA changed the cell's instructions for making certain proteins, which impacted blood cell shape.CThe change in DNA changed the cell's instructions for making certain lipids, which impacted blood cell shape.DThe change in DNA changed the cell's instructions for making certain carbohydrates, lipids, and proteins- all of which together impacted blood cell shape.Skip For Now

Select the ways that sickle-cell disease impacts the body.

Sickle cell anemia is caused by a allele because this mutation has more than one effect on the phenotype.

How does sickle-cell disease impact the circulatory system?

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