Which of the following is not true about a body that starts to produce ketone bodies (i.e. ketogenesis)?Group of answer choicesA) The citric acid cycle intermediates of most cells are depleted due to using those intermediates for gluconeogenesis.B) Glycogen storage in the liver and muscle are depleted or very low.C) The liver has been exporting glucose for extra hepatic tissues to use as fuel.D) Fatty acid oxidation in the liver will slow down or stop as a result of ketogenesis.
Question
Which of the following is not true about a body that starts to produce ketone bodies (i.e. ketogenesis)?Group of answer choicesA) The citric acid cycle intermediates of most cells are depleted due to using those intermediates for gluconeogenesis.B) Glycogen storage in the liver and muscle are depleted or very low.C) The liver has been exporting glucose for extra hepatic tissues to use as fuel.D) Fatty acid oxidation in the liver will slow down or stop as a result of ketogenesis.
Solution
The statement that is not true about a body that starts to produce ketone bodies (i.e., ketogenesis) is:
D) Fatty acid oxidation in the liver will slow down or stop as a result of ketogenesis.
Explanation:
A) The citric acid cycle intermediates of most cells are depleted due to using those intermediates for gluconeogenesis. - This is true. During starvation or carbohydrate restriction, the body uses gluconeogenesis to produce glucose. This process uses citric acid cycle intermediates, depleting them.
B) Glycogen storage in the liver and muscle are depleted or very low. - This is also true. Glycogen stores are used up when the body is not getting enough glucose from the diet, such as during fasting or carbohydrate restriction.
C) The liver has been exporting glucose for extra hepatic tissues to use as fuel. - This is true. The liver exports glucose to other tissues in the body for energy when glucose intake is low.
D) Fatty acid oxidation in the liver will slow down or stop as a result of ketogenesis. - This is not true. In fact, the opposite is true. When the body is in a state of ketogenesis, it is breaking down fatty acids in the liver to produce ketone bodies for energy. Therefore, fatty acid oxidation in the liver actually increases during ketogenesis.
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