Which of the following statements about cancer cells is correct?1. Passenger mutations can occur without the onset of a tumor.2. Cancer cells are derived from a clone.3. Accumulation of driver mutations can lead to cancer.4. Intratumoral heterogeneity provides a good rationale for advancing precision medicine.A. 1, 2 and 3B. 1 and 3C. 2 and 4D. 4 onlyE. All of 1, 2, 3 and 4 are correct.23. Which of the following statements about genetics of Alzheimer’s Disease (AD) is correct?A. Mutations in presenilin 1 or 2 can lead to AD.B. Production of ApoE3 can lead to AD.C. Trisomy 21 decreases the probability of early onset.D. Decrease in β-secretase can lead to AD.24. Theoretically, which of the following could be used as a biomarker (something you test for to see if thedisease could be present) for Alzheimer’s Disease?1. Hyperphosphorylated Tau.2. 42aa β-amyloid peptide.3. Acetylcholine production.4. Glutamate production.A. 1, 2 and 3B. 1 and 3C. 2 and 4D. 4 onlyE. All of 1, 2, 3 and 4 are correct.
Question
Which of the following statements about cancer cells is correct?1. Passenger mutations can occur without the onset of a tumor.2. Cancer cells are derived from a clone.3. Accumulation of driver mutations can lead to cancer.4. Intratumoral heterogeneity provides a good rationale for advancing precision medicine.A. 1, 2 and 3B. 1 and 3C. 2 and 4D. 4 onlyE. All of 1, 2, 3 and 4 are correct.23. Which of the following statements about genetics of Alzheimer’s Disease (AD) is correct?A. Mutations in presenilin 1 or 2 can lead to AD.B. Production of ApoE3 can lead to AD.C. Trisomy 21 decreases the probability of early onset.D. Decrease in β-secretase can lead to AD.24. Theoretically, which of the following could be used as a biomarker (something you test for to see if thedisease could be present) for Alzheimer’s Disease?1. Hyperphosphorylated Tau.2. 42aa β-amyloid peptide.3. Acetylcholine production.4. Glutamate production.A. 1, 2 and 3B. 1 and 3C. 2 and 4D. 4 onlyE. All of 1, 2, 3 and 4 are correct.
Solution
Sure, I can help with that. Here are the answers to your questions:
For the first question about cancer cells, the correct answer is E. All of 1, 2, 3 and 4 are correct. This is because passenger mutations can occur without the onset of a tumor, cancer cells are indeed derived from a clone, the accumulation of driver mutations can lead to cancer, and intratumoral heterogeneity does provide a good rationale for advancing precision medicine.
For the second question about the genetics of Alzheimer’s Disease (AD), the correct answer is A. Mutations in presenilin 1 or 2 can lead to AD. The other options are incorrect because production of ApoE3 does not lead to AD, trisomy 21 actually increases the probability of early onset, and a decrease in β-secretase does not lead to AD.
For the third question about potential biomarkers for Alzheimer’s Disease, the correct answer is A. 1, 2 and 3. Hyperphosphorylated Tau, 42aa β-amyloid peptide, and acetylcholine production could all theoretically be used as biomarkers for Alzheimer’s Disease. Glutamate production is not typically associated with Alzheimer’s Disease.
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