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Hemophilia is a sex-linked recessive disorder.  A man with hemophilia mates with a woman who is a carrier for the disease.  What is the genotype of the man?

Question

Hemophilia is a sex-linked recessive disorder.  A man with hemophilia mates with a woman who is a carrier for the disease.  What is the genotype of the man?

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Solution

The genotype of the man with hemophilia is X^hY. This is because hemophilia is a sex-linked recessive disorder that is carried on the X chromosome. Men have one X and one Y chromosome (XY), and women have two X chromosomes (XX).

In this case, the man has the hemophilia disorder, which means he carries the hemophilia gene on his X chromosome. We denote the hemophilia gene as X^h. The Y chromosome doesn't carry the hemophilia gene. Therefore, the man's genotype is X^hY.

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