Which statement regarding GPCRs as drug targets is FALSE?Group of answer choicesThe most targeted GPCRs for drug development belong to nonrhodopsin class A.Beta blockers are beta1 adrenergic receptor antagonists that act to slow heart rate and force of contraction to treat hypertension.Orphan GPCRs are considered to have untapped potential as new drug targets.GPCRs as a family are only activated by amino acids and their derivatives like epinephrine, glutamate and dopamine.

Roughly twice as many pharmaceuticals target GPCRs versus nuclear receptors.Group of answer choicesTrueFalse

Which of the following statements is (are) trueabout the G-protein coupled receptors (GPCRs)?A.There are only a few GPCRs in the human genome.B.When a signal molecule binds to the GPCR it causesphosphorylation of the GPCR that allows the G-proteinto bind.C.GPCRs act as GEFs for specific G-proteins.D.They are peripheral proteins composed of multiplepolypeptides.

Which one of the following statements regarding angiotensin AT1 receptor antagonists for the treatment of hypertension is correct?Group of answer choicesThey lower blood pressure via decreased angiotensin II levels.They decrease total peripheral resistance.They cause a dry cough.They decrease circulating angiotensin I levels.

Which one of the following statements about µ-opioid receptors is INCORRECT?Group of answer choicesThey are Gi-coupled G protein-coupled receptors (GPCRs).Antagonists of µ-opioid receptors are useful analgesic agents.The brain and spinal cord are densely populated with µ-opioid receptors.µ-opioid receptors are found in gastrointestinal tissues.

With which of the following classes of drugs should you consider using a reduced dose of epinephrine when using an epinephrine-containing local anesthetic solution?I. Beta blockersII. ImmunosuppressantsIII. Tricyclic antidepressantsIV. Loop diuretics